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The fibrotic liver disease that is associated with Biliary Atresia (BA) impacts the likelihood of survival with native liver. Our previously research demonstrated the potential for a certain profibrotic signaling pathway to be active in BA. Using a mouse model of BA and human liver gene expression data collected by ChiLDReN, we were able to confirm the likely activation of this pathway known as TWEAK/FN14 in association with liver fibrosis. We further showed that inhibition of this pathway pharmacologically was associated with near complete elimination of fibrosis in the mouse model of BA. These observations suggest that focus on this signaling pathway warrants further study as we seek novel ways to care for infants with BA.
Arbor Research Collaborative for Health has been awarded a new contract to develop and operate a secure, scalable, and innovative data registry system in support of Michigan’s Obstetrics Initiative (OBI). The initiative, one of several state-wide Collaborative Quality Initiatives (CQI), aims to improve maternal and neonatal outcomes across the state through advanced data-driven insights and